Recombinant Human CD93/C1QR1 Protein (aa 1-580, His Tag)

Specifications

Catalog number

PKSH030806

Size / count

50 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protein expressed on monocytes; neutrophils; endothelial cells; and stem cells. CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. CD93/C1qR; a receptor expressed during early B-cell development; is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive; memory; and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre) plasmablasts/plasma cells; including long-lived plasma cells that showed decreased cell cycle activity; high levels of isotype-switched Ig secretion; and modification of the transcriptional network. CD93 is important for the maintenance of plasma cells in bone marrow niches.

Synonyms

C1QR1; C1q/MBL/SPA Receptor; C1qR; C1qR (p) ; C1qRp; CDw93; Complement Component 1 q Subcomponent Receptor 1; Complement Component C1q Receptor; MXRA4; Matrix-Remodeling-Associated Protein 4CD93

UniProt

Q9NPY3

Accession Number

Q9NPY3

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Lys 580

Field of Research

Cardiovascular; immunology; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

59.6 kDa

Observed Molecular Weight

100 kDa

Species

Human