Recombinant Human FABP3 Protein

Specifications

Catalog number

PKSH030830

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Fatty acid binding protein 3 (FABP3; also termed heart-type fatty acid binding protein) is a member of the intracellular lipid-binding protein family that may be essential in fatty acid transport; cell growth; cellular signaling and gene transcription. Previously FABP3 was involved in apoptosis-associated congenital cardiac malformations. FABP3 knockdown exhibited significant toxic effects on cardiac development and mitochondrial function; which may be responsible for the knockdown of FABP3-induced apoptosis. FABP3 as a candidate gene underlying the etiology of congenital heart defects. Overexpression of FABP3 inhibited cell growth and proliferation via negative regulation of the cell cycle and down-regulation of cell growth factors; but enhances cell survival in hypoxic or ischemic conditions. FABPs are known to be carrier proteins for transporting fatty acids and other lipophilic substances from the cytoplasm to the nucleus; where these lipids are released to a group of nuclear receptors such as peroxisome proliferator-activated receptors (PPARs) .

Synonyms

FABP11; FABP3; Fatty Acid-Binding Protein 3; Fatty Acid-Binding Protein Heart; H-FABP; Heart-Type Fatty Acid-Binding Protein; M-FABP; MDGI; MDGIMuscle Fatty Acid-Binding Protein; Mammary-Derived Growth Inhibitor; O-FABP

UniProt

P05413

Accession Number

P05413

Expression System

E.coli

Tag

None

Sequence

Met 1-Ala 133

Field of Research

Signal Transduction; Cardiovascular; Cancer; metabolism

Endotoxin

Please contact us for more information.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

14.9 kDa

Species

Human