Recombinant Human CD300a/LMIR1 Protein (Fc Tag)

Specifications

Catalog number

PKSH030836

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CMRF35-like molecule 8; also known as CD300 antigen-like family member A; CMRF35-H9; Immunoglobulin superfamily member 12; Inhibitory receptor protein 60; NK inhibitory receptor; CD300a and CMRF35H; is a single-pass type I membrane protein which belongs to theCD300 family. The CD300 family of myeloid immunoglobulin receptors includes activating (CD300b; CD300e) and inhibitory members (CD300a; CD300f) ; as well as molecules presenting a negative charge within their transmembrane domain (CD300c; CD300d) . CD300A / IGSF12 is expressed not only by natural killer (NK) cells but also by T-cell subsets; B-cells; dendritic cells; mast cells; granulocytes and monocytes.It contains oneIg-like V-type (immunoglobulin-like) domain. CD300A / IGSF12 is an inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells; and to the down-regulation of mast cell degranulation. CD300c is a functional immune receptor able to deliver activating signals upon ligation in RBL-2H3 mast cells. CD300c signaling is partially mediated by a direct association with the immune receptor tyrosine-based activation motif-bearing adaptor FcεRγ. CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from plasmacytoid dendritic cells (pDCs) .

Synonyms

CD300 Antigen-Like Family Member A; CD300A; CD300a; CLM-8; CMRF-35-H9; CMRF35-H; CMRF35-H9; CMRF35-Like Molecule 8; CMRF35H; IGSF12; IRC1/IRC2; IRp60; IgSF12; Immunoglobulin Superfamily Member 12; Inhibitory Receptor Protein 60; NK Inhibitory Receptor

UniProt

Q9UGN4

Accession Number

Q9UGN4-1

Expression System

HEK293 Cells

Tag

C-hFc

Sequence

Met 1-Gln178

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

44.5 kDa

Observed Molecular Weight

58-66 kDa

Species

Human