Recombinant Human DIM1/TXNL4A Protein (His Tag)

Specifications

Catalog number

PKSH030841

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

DIM1, also known as TXNL4A, is a member of the Dim protein family. The Dim protein family is composed of two classes, DIM1and Dim2, which share a common thioredoxin-like fold. They were originally identified for their role in cell cycle progression and have been found to interact with Prp6, an essential component of the spliceosome, which forms the bridge of U4/U6.U5-tri-snRNP. In spite of their biological and structural similarities, DIM1 and Dim2 proteins differ in many aspects. DIM1 bears distinctive structural motifs responsible for its interaction with other spliceosome components. Dim2 forms homodimers and contains specific domains required for its interactions with partners. This originality suggests that although both proteins are involved in pre-mRNA splicing, they are likely to be involved in different biological pathways. DIM1 interacts with HNRPF, HNRPH2, NEDD9/HEF1 and PQBP1/NPW38. It plays an essential role in pre-mRNA splicing.

Synonyms

BMKS; DIB1; DIM1; SNRNP15; TXNL4; U5-15kD

UniProt

P83876

Accession Number

P83876

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Tyr 142

Field of Research

Epigenetics and nuclear signal

Endotoxin

Please contact us for more information.

Purity

> 94 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

18.6 kDa

Observed Molecular Weight

16 kDa

Species

Human