Recombinant Human C1D Protein (GST Tag)

Specifications

Catalog number

PKSH030842

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

C1D nuclear receptor corepressor belongs to the C1D family. It is a DNA binding and apoptosis-inducing protein.C1D nuclear receptor corepressorinteracts with TSNAX and DNA-PKcs. It acts as a corepressor for the thyroid hormone receptor. It is thought that C1D nuclear receptor corepressor regulates TRAX/Translin complex formation. It is expressed in kidney, heart, brain, spleen, lung, testis, liver and small intestine. It plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. It potentiates transcriptional repression by NR1D1 and THRB. C1D nuclear receptor corepressorcan activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. It also can induce apoptosis in a p53/TP53 dependent manner.

Synonyms

LRP1; Rrp47; SUN-CoR; SUNCOR; hC1D

UniProt

Q13901

Accession Number

Q13901

Expression System

E.coli

Tag

N-GST

Sequence

Met 1-Ser 141

Field of Research

Signal Transduction; Cell biology; epigenetics and nuclear signal; immunology

Endotoxin

Please contact us for more information.

Purity

> 80 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

43.2 kDa

Observed Molecular Weight

43 kDa

Species

Human