Recombinant Human CD160/BY55 Protein (aa 1-158, His Tag)

Specifications

Catalog number

PKSH030878

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD160 antigen, also known as Natural killer cell receptor BY55 and CD160, is a cell membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic CD56 (dim) CD16 (+) peripheral blood NK subset. CD160 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD160 is expressed in spleen, peripheral blood, and small intestine. Expression of CD160 is restricted to functional NK and T cytotoxic lymphocytes. CD160 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD160+ T cells isolated from inflammatory skin lesions. Unique CD4+ CD160+ lymphocyte subset may play a role in the pathogenesis of skin inflammation. Activated NK lymphocytes release a soluble form of CD160 that functionally impairs the MHC-I-specific cytotoxic CD8 (+) T lymphocyte responsiveness.

Synonyms

BY55; CD160; CD160 Antigen; NK1; NK28; Natural Killer Cell Receptor BY55

UniProt

O95971

Accession Number

NP_008984.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Leu 158

Applications

ELISA

Field of Research

Cardiovascular; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Measured by its ability to bind with biotinylated human HVEM-Fch in a functional ELISA.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

16.4 kDa

Observed Molecular Weight

25 kDa

Species

Human