Recombinant Human PROS1/Protein S Protein (His Tag)

Specifications

Catalog number

PKSH030881

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

PROS1, also known as protein S, is a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. PROS1 has two isoforms: a free, functionally active form and an inactive form complexed with C4b-binding protein. Besides its anticoagulant function, PROS1 also acts as an agonist for the tyrosine kinase receptors Tyro3, Axl, and Mer. The endothelium expresses Tyro3, Axl, and Mer and produces protein S. The interaction of protein S with endothelial cells and particularly its effects on angiogenesis have not yet been analyzed.

Synonyms

PROS; PS21; PS22; PS23; PS24; PS25; PSA; Protein S; THPH5; THPH6

UniProt

P07225

Accession Number

P07225

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Ser676

Field of Research

Cardiovascular

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

74.1 kDa

Observed Molecular Weight

69-89 kDa

Species

Human