Recombinant Human ULBP2/N2DL-2 Protein (Fc Tag)

Specifications

Catalog number

PKSH030893

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

NKG2D ligand 2; also known as N2DL-2; NKG2DL2; ALCAN-alpha; Retinoic acid early transcript 1H; UL16-binding protein 2; ULBP2 and N2DL2; is cell membrane protein which belongs to theMHC class I family. ULBP2 / N2DL-2 is expressed in various types of cancer cell lines and in the fetus; but not in normal tissues. ULBP2 / N2DL-2 is a ligand for the NKG2D receptor; together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells; resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2; STAT5; ERK and PI3K kinase/Akt signal transduction pathway.

Synonyms

ALCAN-Alpha; N2DL-2; N2DL2; NKG2D Ligand 2; NKG2DL2; RAET1H; Retinoic Acid Early Transcript 1H; UL16-Binding Protein 2; ULBP2

UniProt

Q9BZM5

Accession Number

Q9BZM5

Expression System

HEK293 Cells

Tag

C-hFc

Sequence

Met 1-Ser 217

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

48.7 kDa

Observed Molecular Weight

58 kDa

Species

Human