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Product details

Recombinant Human Pepsinogen C/PGC Protein (HEK293 Cells, His Tag)

Catalog number PKSH030916

Price for PKSH030916

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Size / count 20 µg

Specifications

Catalog number
PKSH030916
Size / count
20 µg
Dry ice
No
Hazardous
No
Discontinued
No
Background
Pepsinogen C, also known as PGC, is an aspartic proteinase that belongs to the peptidase family A1. Pepsinogen C is synthesized in the gastric mucosa as inactive precursors, known as zymogens. Pepsinogen C contains a prosegment that serves to stabilize the inactive form and prevent entry of the substrate to the active site. At low PH conditions, Pepsinogen C undergoes conversion into active enzyme. Pepsinogen C has been found expressed in all regions of the stomach mucosa and also in the proximal duodenal mucosa. In stomach cancer tissues and cancer cell lines, the expressions of the pepsinogen genes were decreased or lost, in good accordance with their pepsinogen productions. No gross structural changes of the pepsinogen genes were observed in these cancers, but the methylation patterns of the pepsinogen genes were found to be altered in different ways in different cancers. Serum levels of Pepsinogen C are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.
Synonyms
PEPC; PGII
UniProt
P20142
Accession Number
NP_002621.1
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met 1-Ala 388
Field of Research
Signal Transduction; Microbiology; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
42 kDa
Observed Molecular Weight
42 kDa
Species
Human

Frequently Asked Questions

What is the catalog number for Recombinant Human Pepsinogen C/PGC Protein (HEK293 Cells, His Tag)?

The catalog number for Recombinant Human Pepsinogen C/PGC Protein (HEK293 Cells, His Tag) is PKSH030916.

What sizes are available for Recombinant Human Pepsinogen C/PGC Protein (HEK293 Cells, His Tag)?

Recombinant Human Pepsinogen C/PGC Protein (HEK293 Cells, His Tag) is available in the following size(s): 20 µg.

Is Recombinant Human Pepsinogen C/PGC Protein (HEK293 Cells, His Tag) in stock?

Recombinant Human Pepsinogen C/PGC Protein (HEK293 Cells, His Tag) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant Human Pepsinogen C/PGC Protein (HEK293 Cells, His Tag)?

Recombinant Human Pepsinogen C/PGC Protein (HEK293 Cells, His Tag) is manufactured by Elabscience.

What is the estimated delivery time for Recombinant Human Pepsinogen C/PGC Protein (HEK293 Cells, His Tag)?

Estimated delivery time for Recombinant Human Pepsinogen C/PGC Protein (HEK293 Cells, His Tag) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant Human Pepsinogen C/PGC Protein (HEK293 Cells, His Tag)?

The safety data sheet for Recombinant Human Pepsinogen C/PGC Protein (HEK293 Cells, His Tag) is available here: https://789.bio/eb/ezn9SO.

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

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