Recombinant Human WFIKKN2/GASP-1 Protein (His Tag)

Specifications

Catalog number

PKSH030936

Size / count

50 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 2, also known as Growth and differentiation factor-associated serum protein 1, WAP, follistatin, immunoglobulin, kunitz and NTR domain-containing-related protein, WFIKKN-related protein, WFIKKN2 and GASP1, is a secreted protein which belongs to theWFIKKN family. WFIKKN2 contains twoBPTI/Kunitz inhibitor domains, oneIg-like C2-type (immunoglobulin-like) domain, oneKazal-like domain, oneNTR domain and oneWAP domain. WFIKKN2 is primarily expressed in ovary, testis and brain, but not in liver. In fetal tissues, it is primarily expressed in brain, skeletal muscle, thymus and kidney. WFIKKN2 is protease-inhibitor that contains multiple distinct protease inhibitor domains. It probably has serine protease- and metalloprotease-inhibitor activity. It inhibits the biological activity of mature myostatin, but not activin. WFIKKN2 protein binds mature GDF8/myostatin and myostatin propeptide and inhibits the biological activity of myostatin.

Synonyms

GASP-1; WFDC20B; WFIKKNRP; hGASP-1

UniProt

Q8TEU8

Accession Number

NP_783165.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-His 576

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 96 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

61.4 kDa

Observed Molecular Weight

70-75 kDa

Species

Human