Recombinant Human SLAMF6/Ly108 Protein (aa 1-226, His Tag)

Specifications

Catalog number

PKSH030961

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

SLAM family member 6; also known as Activating NK receptor; NK-T-B-antigen; NTB-A; SLAMF6; KALI and Ly108; is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly108 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK) ; T- and B-lymphocytes. SLAMF6 / Ly108 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly108 is a homodimer. It interacts with PTN6 and; upon phosphorylation; with PTN11 and SH2D1A/SAP. SLAMF6 / Ly108 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs) . It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly108 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

Synonyms

Activating NK Receptor; CD352; KALI; Ly108; NK-T-B-Antigen; NTB-A; NTBA; SF2000; SLAM Family Member 6; SLAMF6

UniProt

Q96DU3

Accession Number

Q96DU3-1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Met 226

Applications

ELISA

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Measured by its ability to bind biotinylated recombinant human SH2D1A in a functional ELISA.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

24.3 kDa

Observed Molecular Weight

38-40 kDa

Species

Human