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Product details

Recombinant Human Tryptophan Hydroxylase 1/TPH1 Protein (His Tag)

Catalog number PKSH030968

Price for PKSH030968

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Size / count 50 µg

Specifications

Catalog number
PKSH030968
Size / count
50 µg
Dry ice
No
Hazardous
No
Discontinued
No
Background
Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, Tryptophan hydroxylase 1, TPH1, TPH and TPRH, is anenzyme which belongs to thebiopterin-dependent aromatic amino acid hydroxylase family. TPH1 contains oneACT domain. Tryptophan hydroxylase catalyzes the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. TPH1 expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells.The tryptophan hydroxylase 1 (TPH1) gene is also reported to be associated with suicidal behavior. Polymorphisms of TPH1 may assist in identifying a subgroup of mood disorder patients that is at higher risk for suicidal behavior.
Synonyms
TPRH; TRPH
UniProt
P17752
Accession Number
P17752-1
Expression System
E.coli
Tag
N-His
Sequence
Ile 2-Ile 444
Field of Research
Signal Transduction, Neuroscience, Cancer, Metabolism
Endotoxin
Please contact us for more information.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
52.7 kDa
Observed Molecular Weight
48 kDa
Species
Human

Frequently Asked Questions

What is the catalog number for Recombinant Human Tryptophan Hydroxylase 1/TPH1 Protein (His Tag)?

The catalog number for Recombinant Human Tryptophan Hydroxylase 1/TPH1 Protein (His Tag) is PKSH030968.

What sizes are available for Recombinant Human Tryptophan Hydroxylase 1/TPH1 Protein (His Tag)?

Recombinant Human Tryptophan Hydroxylase 1/TPH1 Protein (His Tag) is available in the following size(s): 50 µg.

Is Recombinant Human Tryptophan Hydroxylase 1/TPH1 Protein (His Tag) in stock?

Recombinant Human Tryptophan Hydroxylase 1/TPH1 Protein (His Tag) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant Human Tryptophan Hydroxylase 1/TPH1 Protein (His Tag)?

Recombinant Human Tryptophan Hydroxylase 1/TPH1 Protein (His Tag) is manufactured by Elabscience.

What is the estimated delivery time for Recombinant Human Tryptophan Hydroxylase 1/TPH1 Protein (His Tag)?

Estimated delivery time for Recombinant Human Tryptophan Hydroxylase 1/TPH1 Protein (His Tag) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant Human Tryptophan Hydroxylase 1/TPH1 Protein (His Tag)?

The safety data sheet for Recombinant Human Tryptophan Hydroxylase 1/TPH1 Protein (His Tag) is available here: https://789.bio/eb/WnvjXH.

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.

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