Recombinant Human C1QBP Protein (aa 75-282, His Tag)

Specifications

Catalog number

PKSH030979

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Hyaluronan binding protein 1 (HABP1), also known as p32 or gC1qR, is a ubiquitously expressed multifunctional phospho-protein implicated in cell signalling. Hyaluronan-binding protein 1 (HABP1) /p32/gC1qR was characterized as a highly acidic and oligomeric protein, which binds to different ligands like hyaluronan, C1q, and mannosylated albumin. The role of hyaluronan binding protein 1 (HABP1) in cell signaling was investigated and in vitro. HABP1 overexpressing cells showed extensive vacuolation and reduced growth rate, which was corrected by frequent medium replenishment. Further investigation revealed that HABP1 overexpressing cells undergo apoptosis, and they failed to enter into the S-phase. The sperm surface HABP1 level can be correlated with the degree of sperm motility.Hyaluronan binding protein 1 (HABP1) was reported to be present on human sperm surface and its involvement in fertilization has already been elucidated: decreased HABP1 level may be associated with low motility of sperms, which in turn might cause infertility in the patient. HABP1 also is an endogenous substrate for MAP kinase and upon mitogenic stimulation it is translocated to the nucleus in a MAP kinase-dependent manner.

Synonyms

ASF/SF2-Associated Protein p32; C1QBP; C1qBP; Complement Component 1 Q Subcomponent-Binding Protein Mitochondrial; GC1QBP; Glycoprotein gC1qBP; HABP1; Hyaluronan-Binding Protein 1; Mitochondrial Matrix Protein p32; SF2P32; gC1q-R Protein; gC1qR; p33

UniProt

Q07021

Accession Number

NP_001203.1

Expression System

E.coli

Tag

C-His

Sequence

His 75-Gln 282

Field of Research

Microbiology; immunology

Endotoxin

Please contact us for more information.

Purity

> 96 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

24.8 kDa

Observed Molecular Weight

36 kDa

Species

Human