Recombinant Human IL17RC Protein (Fc Tag)

Specifications

Catalog number

PKSH031013

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Plexin domain-containing protein 1; also known as tumor endothelial marker 3; tumor endothelial marker 7 and PLXDC1 and TEM3; is a secreted; cytoplasm and single-pass type I membrane protein which belongs to theplexin family. PLXDC1 / TEM3 is detected in endothelial cells from colorectal cancer; and in endothelial cells from primary cancers of the lung; liver; pancreas; breast and brain. It is expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy. PLXDC1 / TEM3 is not detectable in endothelial cells from normal tissue. PLXDC1 / TEM3 plays a critical role in endothelial cell capillary morphogenesis. PLXDC1 / TEM3 may play a significant role in the proliferation and maintenance of neovascular endothelial cells in the formation of fibrovascular membranes (FVMs) . PLXDC1 / TEM3 may be a molecular target for new diagnostic and therapeutic strategies for proliferative diabetic retinopathy (PDR) . PLXDC1 / TEM3 interacts with NID1. It may also interact with CTTN.

Abbreviation

IL17RC

Synonyms

UNQ; IL17RC; UNQ6118; PRO20040; PRO38901; IL17RL; IL17-RL; UNQ6118/PRO20040/PRO38901

UniProt

Q8NAC3

Accession Number

NP_116121.2

Expression System

HEK293 Cells

Tag

C-hFc

Sequence

Met 1-Ala 454

Applications

ELISA

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Measured by its ability to bind with recombinant human IL17A-His in a functional ELISA.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

75.3 kDa

Observed Molecular Weight

100-120 kDa

Species

Human