Recombinant Human NTPDase 2/ENTPD2 Protein (aa 29-460, His Tag)

Specifications

Catalog number

PKSH031019

Size / count

50 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

NTPDase 2, also known as ENTPD2, belongs to the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase) . Members of E-NTPDase family are nucleotidases able to hydrolyze 5′ -nucleoside tri- and/or diphosphates; the main role of these enzymes is the termination of purinergic signaling. NTPDases are ubiquitous and were previously shown in other parasites including the trypanosomatides of genus Leishmania and in T. brucei. NTPase activity would act as a timer and is crucial to T. gondii infection. In L. pneumophila it was demonstrated that an E-NTPDase, similar to CD39, is essential for intracellular bacterial multiplication. NTPDase 2 is an integral membrane protein. In the nervous system, it could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Alternative splicing of NTPDase 2 gene results in multiple transcript variants.

Synonyms

CD39L1; NTPDase-2; RP11-229P13.11-001

UniProt

Q9Y5L3

Accession Number

Q9Y5L3

Expression System

Baculovirus-Insect Cells

Tag

N-His

Sequence

Thr 29-Asp460

Field of Research

Neuroscience; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 85 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

49.3 kDa

Observed Molecular Weight

59 kDa

Species

Human