Recombinant Human SPINK4 Protein (His Tag)

Specifications

Catalog number

PKSH031033

Size / count

50 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Serine protease inhibitor Kazal-type 4; also known as Peptide PEC-60 homolog and SPINK4; is a secreted protein which contains one Kazal-like domain. SPINK4 is a member of the SPINK protein family. The gene family of serine protease inhibitors of the Kazal type (SPINK) are functional and positional candidate genes for celiac disease (CD) . SPINK1 plays an important role in protecting the pancreas against excessive trypsinogen activation. It is a potent natural inhibitor of pancreatic trypsin activity. SPINK1 mutations are associated with the development of acute and chronic pancreatitis and have been detected in all forms of chronic pancreatitis. SPINK2 functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges. SPINK9 was identified in human skin. Its expression was strong in palmar epidermis; but not detectable or very low in non palmoplantar skin.

Synonyms

HEL136; MGC133107; PEC-60; PEC60; Peptide PEC-60 Homolog; SPINK4; Serine Protease Inhibitor Kazal-Type 4

UniProt

O60575

Accession Number

NP_055286.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Cys 86

Field of Research

Cell biology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 97 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

8.0 kDa

Observed Molecular Weight

10 kDa

Species

Human