Recombinant Human TREML2/TLT2 Protein (His Tag)

Specifications

Catalog number

PKSH031041

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I membrane protein which contains oneIg-like V-type (immunoglobulin-like) domain. TREML2 is detected in cultured B cells, T cell leukemia and monocyte leukemia. TREML2 is expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. TREML2 is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML2 acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. Murine B7-H3 specifically bound to Triggering receptor expressed on myeloid cells (TREM) -like transcript 2 (TLT-2, TREML2) . TREML2 was expressed on CD8 (+) T cells constitutively and on activated CD4 (+) T cells. Stimulation with B7-H3 transfectants preferentially up-regulated the proliferation and IFN-gamma production of CD8 (+) T cells. Transduction of TREML2 into T cells resulted in enhanced IL-2 and IFN-gamma production via interactions with B7-H3. There maybe a direct interaction between B7-H3 and TREML2 that preferentially enhances CD8 (+) T cell activation.

Synonyms

C6orf76; TLT2; Trem-like transcript 2 protein; Triggering receptor expressed on myeloid cells-like protein 2

UniProt

Q5T2D2

Accession Number

NP_079083.2

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Ser 268

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

28.5 kDa

Observed Molecular Weight

55-60 kDa

Species

Human