Recombinant Human ATF2 Protein (His & GST Tag)

Specifications

Catalog number

PKSH031071

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Activating transcription factor 2, also known as ATF2, is a member of the leucine zipper family of DNA-binding proteins that binds to the cAMP response element. Its activity is enhanced after phosphorylation by stress-activated protein kinases such as c-Jun N-terminal kinase and p38. ATF2 has been found to be a target of the JNK signal transduction pathway and mediate adenovirus E1A-inducible transcriptional activation. ATF2 is also been reported playing roles in TGF-β signaling pathway. It has been shown that the transcription factor ATF2 is bound by a hetero-oligomer of Smad3 and Smad4 upon TGF-β stimulation. Studies indicate that ATF-2 plays a central role in TGF-β signaling by acting as a common nuclear target of both Smad and TAK1 pathways.

Synonyms

CRE-BP1; CREB-2; CREB2; HB16; TREB7

UniProt

P15336

Accession Number

P15336-1

Expression System

Baculovirus-Insect Cells

Tag

N-His-GST

Sequence

Met 1-Ser 505

Field of Research

Epigenetics and Nuclear Signaling, Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

82.4 kDa

Observed Molecular Weight

85 kDa

Species

Human