Recombinant Human SULT2A1 Protein (His Tag)

Specifications

Catalog number

PKSH031126

Size / count

50 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Hydroxysteroid sulfotransferase (SULT2A1) is a key enzyme in the testicular and hepatic metabolism of 5alpha-androstenone, which is a major component of the off-odor and off-flavor in pork known as boar taint. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. SULT2A1 is a sulfo-conjugating phase II enzyme expressed at very high levels in the liver and intestine, the two major first-pass metabolic tissues, and in the steroidogenic adrenal tissue. SULT2A1 acts preferentially on the hydroxysteroids dehydroepiandrosterone, testosterone/dihydrotestosterone, and pregnenolone and on cholesterol-derived amphipathic sterol bile acids.

Synonyms

Bile Salt Sulfotransferase; DHEA-ST; DHEAS; Dehydroepiandrosterone Sulfotransferase; HST; Hydroxysteroid Sulfotransferase; ST2; ST2A1; ST2A3; STD; SULT2A1; Sulfotransferase 2A1

UniProt

Q06520

Accession Number

NP_003158.2

Expression System

E.coli

Tag

N-His

Sequence

Ser 2-Glu 285

Field of Research

Signal Transduction; Cancer; metabolism

Endotoxin

Please contact us for more information.

Purity

> 97 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

34.5 kDa

Observed Molecular Weight

35 kDa

Species

Human