Recombinant Human SULT2B1 Protein (aa 2-365, His Tag)

Specifications

Catalog number

PKSH031127

Size / count

50 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Sulfotransferase family cytosolic 2B member 1; also known as Sulfotransferase 2B1; ST2B1; Alcohol sulfotransferase; Hydroxysteroid sulfotransferase 2; SULT2B1 and HSST2; is a cytoplasm protein which belongs to thesulfotransferase 1 family. The human hydroxysteroid sulfotransferase (SULT) family is comprised of two subfamilies; SULT2A1 and SULT2B1. SULT2B1 is expressed highly in placenta; prostate and trachea. A lesser expression of SULT1B1 was observed in the small intestine and lung. SULT2B1 catalyzes the sulfate conjugation of many hormones; neurotransmitters; drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds; and therefore their renal excretion; but it can also result in bioactivation to form active metabolites. SULT2B1 sulfates hydroxysteroids like DHEA. Isoform1 preferentially sulfonates cholesterol. The two SULT2B1 isoforms; SULT2B1a and SULT2B1b; are encoded by a single gene as a result of alternative transcription initiation and alternative splicing. SULT2B1b catalyzes the sulfonation of 3beta-hydroxysteroid hormones and cholesterol; whereas SULT2B1a preferentially catalyzes pregnenolone sulfonation.

Synonyms

Alcohol Sulfotransferase; HSST2; Hydroxysteroid Sulfotransferase 2; ST2B1; SULT2B1; Sulfotransferase 2B1; Sulfotransferase Family Cytosolic 2B Member 1

UniProt

O00204

Accession Number

NP_004596.2

Expression System

E.coli

Tag

N-His

Sequence

Asp 2-Ser 365

Field of Research

Signal Transduction; Cardiovascular; Cancer; metabolism

Endotoxin

Please contact us for more information.

Purity

> 76 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

42 kDa

Observed Molecular Weight

44 kDa

Species

Human