Recombinant Human OSMR/IL31RB Protein (aa 1-740, His Tag)

Specifications

Catalog number

PKSH031191

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the type I cytokine receptor family. IL-31RB/OSMR heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in IL-31RB/OSMR have been associated with familial primary localized cutaneous amyloidosis. Defects in IL-31RB/OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1), also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.

Abbreviation

OSMR/IL31RB

Synonyms

PLCA; OSMR; IL-31R-beta; IL-31RB; OSMRB; PLCA1; IL-31 Receptor Subunit Beta; IL-31R Subunit Beta; Interleukin-31 Receptor Subunit Beta; Oncostatin-M specific receptor subunit beta; Oncostatin-M-Specific Receptor Subunit Beta

UniProt

Q99650

Accession Number

NP_003990.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Met 740

Field of Research

Signal Transduction; epigenetics and nuclear signal; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 96 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

82.6 kDa

Observed Molecular Weight

130-140 kDa

Species

Human