Recombinant Human REG4/RELP Protein (Fc Tag)

Specifications

Catalog number

PKSH031222

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP, a member of the regenerating gene family belonging to the calcium (C-type) dependent lectin superfamily, has been found to be involved in malignancy in several different organs including the stomach, colorectum, pancreas and prostate. It is highly expressed in the gastrointestinal tract and markedly up-regulated in colon adenocarcinoma, pancreatic cancer, gastric adenocarcinoma, and inflammatory bowel disease. Expression of the Reg4 in different cell types has been associated with regeneration, cell growth and cell survival, cell adhesion and resistance to apoptosis. REG4 protein overexpression is associated with an unfavorable response to preoperative chemoradiotherapy and may be used as a predictive biomarker clinically. REG4 may play an important role in the development and progression of colorectal cancer, as well as in intestinal morphogenesis and epithelium restitution.

Synonyms

GISP; Gastrointestinal secretory protein; REG-IV; REG-like protein; REG4; RELP; Regenerating islet-derived protein 4; Regenerating islet-derived protein IV

UniProt

Q9BYZ8

Accession Number

Q9BYZ8-1

Expression System

HEK293 Cells

Tag

N-hFc

Sequence

Asp23-Pro158

Field of Research

Immunology, Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

44.3 kDa

Observed Molecular Weight

45 kDa

Species

Human