Recombinant Human CD8 beta/CD8B Protein (Fc Tag)

Specifications

Catalog number

PKSH031296

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD8B (CD8b molecule) ; also known as P37 and LEU2; contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen; acting as a coreceptor; and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains; or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. P37 gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene; also located on chromosome 2; has been identified. CD8 is thought to play a role in the process of T-cell mediated killing.

Synonyms

CD8B; CD8B1; CD8b; LEU2; LY3; LYT3; P37; T-Cell Surface Glycoprotein CD8 Beta Chain

UniProt

P10966

Accession Number

P10966-1

Expression System

HEK293 Cells

Tag

C-hFc

Sequence

Met 1-Pro 170

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 93 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

44.0 kDa

Observed Molecular Weight

50 kDa

Species

Human