Recombinant Human IL-22BP/IL22RA2 Protein (His Tag)

Specifications

Catalog number

PKSH031300

Size / count

50 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin-22 receptor subunit alpha-2 (IL-22RA2) ; also known as interleukin-22-binding protein (IL-22BP) ; is a subunit of the receptor for interleukin 22. IL-22BP belongs to the type I I cytokine receptor family and contains 3 fibronectin type-III domains. IL-22BP/IL-22RA2 is expressed in a range of tissues; including those in the digestive; female reproductive; and immune systems. It is expressed in placenta; spleen; breast; skin and lung. It is also detected in intestinal tract; testis; brain; heart and thymus. The dominant cell types expressing IL-22BP/IL-22RA2 were mononuclear cells and epithelium. IL-22BP/IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important roles in immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptor have been discovered; a membrane-bound receptor and a soluble receptor.

Abbreviation

IL-22BP/IL22RA2

Synonyms

UNQ; Il22ra; IL22RA2; UNQ5793; PRO19598; PRO19822; Class II cytokine receptor; CRF2 10; CRF2 S1; CRF2-10; CRF2-S1; CRF2X; Cytokine receptor class II member 10; Cytokine receptor class-II member 10; Cytokine receptor family 2 member 10; Cytokine receptor family type 2; Cytokine receptor family type 2 soluble 1; I22R2; IL 22 receptor subunit alpha 2; IL 22BP; IL 22R alpha 2; IL 22RA2; IL-22 receptor subunit alpha-2; IL22BP; IL-22BP; IL22R alpha 2; IL-22RA2; IL-22R-alpha-2; Interleukin 22 binding protein; Interleukin 22 Receptor alpha 2; Interleukin-22 receptor subunit alpha-2; Interleukin-22-binding protein; MGC150509; MGC150510; soluble 1; ZcytoR16

UniProt

Q969J5

Accession Number

NP_851826.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Pro 231

Applications

ELISA

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Immobilized IL22BP-His at 10 μg/ml (100 μl/well) can bind biotinylated IL22, The EC50 of biotinylated IL22 is 1.78-4. 14 ng/ml.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

26.1 kDa

Observed Molecular Weight

50-55 kDa

Species

Human