Recombinant Human Troponin C/TNNC1 Protein

Specifications

Catalog number

PKSH031309

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Troponin I, also known as TNNC1, is part of the troponin complex. This complex contains 3 subunits: troponin I (TnI), troponin T (TnT) and troponin C (TnC) . Troponin I is the inhibitory subunit, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle.

Synonyms

CMD1Z; CMH13; TN-C; TNC; TNNC

UniProt

P63316

Accession Number

NP_003271.1

Expression System

E.coli

Tag

None

Sequence

Met 1-Glu161

Field of Research

Signal Transduction; Cardiovascular

Endotoxin

Please contact us for more information.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

18.4 kDa

Observed Molecular Weight

20 kDa

Species

Human