Recombinant Human KIAA0101/p15/PAF Protein (His Tag)

Specifications

Catalog number

PKSH031315

Size / count

50 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

KIAA0101, also known as p15 (PAF), is a proliferating cell nuclear antigen-associated factor which interacts with proliferating cell nuclear antigen (PCNA) . It was initially isolated in a yeast two-hybrid screen for PCNA binding partners, and was shown to bind PCNA competitively with the cell cycle regulator p21 (WAF) . KIAA0101 is localized primarily in the nucleus. It shares the conserved PCNA binding motif with several other PCNA binding proteins including CDK inhibitor p21 . KIAA0101 is involved in cell proliferation and plays a role in early tumor recurrence (ETR), and prognosis of hepatocellular carcinoma (HCC) . KIAA0101 is expressed predominantly in liver, pancreas and placenta. It cannot be detected in heart or brain. It is highly expressed in a number of tumors, especially esophageal tumors, in anaplastic thyroid carcinomas and in non-small-cell lung cancer lines. Overexpression of KIAA0101 predicts high stage, early tumor recurrence, and poor prognosis of hepatocellular carcinoma. It also may be involved in protection of cells from UV-induced cell death.

Synonyms

KIAA0101; L5; NS5ATP9; OEATC; OEATC-1; OEATC1; PAF; PAF15; p15 (PAF) ; p15/PAF; p15PAF

UniProt

Q15004

Accession Number

NP_055551.1

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Glu 111

Field of Research

Cell biology; Cancer; metabolism

Endotoxin

Please contact us for more information.

Purity

> 97 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

13.8 kDa

Observed Molecular Weight

19 kDa

Species

Human