Recombinant Human IL6ST/CD130 Protein (His & Fc Tag)

Specifications

Catalog number

PKSH031330-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM) . CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.

Abbreviation

IL6ST/CD130

Synonyms

CDW; IL6ST; CD130; CDW130; GP130; IL-6RB; Interleukin 6 signal transducer; IR6RB; CD130 antigen; GP130 RAPS; IL 6R beta; IL-6 receptor subunit beta; IL6 ST; IL-6R subunit beta; IL6RB; IL-6R-beta; Interleukin 6 receptor subunit beta; Interleukin receptor beta chain; Interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; Membrane glycoprotein gp130; Oncostatin M receptor; Oncostatin M receptor alpha subunit; Oncostatin-M receptor subunit alpha

UniProt

P40189

Accession Number

NP_002175.2

Expression System

HEK293 Cells

Tag

C-His-Fc

Sequence

Met 1-Ile 618

Applications

Cell culture

Field of Research

Signal Transduction; Cell biology; Cardiovascular; Cancer; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

96.0 kDa

Observed Molecular Weight

125-140 kDa

Species

Human