Recombinant Human IL13RA1 Protein (His & Fc Tag)

Specifications

Catalog number

PKSH031344

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. IL13RA1/IL-13RA1 serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. IL13RA1/IL-13RA1 binds with low affinity to interleukin-13 (IL13) . This subunit together with IL4RA can form a functional receptor for IL13. IL13RA1/IL-13RA1 also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.

Abbreviation

IL13RA1

Synonyms

CD213A; IL13RA1; CD213A1; CT19; IL-13Ra; NR4; IL13R; IL13RA; IL-13Ra1; alpha 1) ; bB128O4.2.1 (interleukin 13 receptor; Cancer/testis antigen 19; CD213A1 Antigen; CT 19; I13R1; IL 13 receptor subunit alpha 1; IL 13R alpha 1; IL 13R subunit alpha 1; IL 13Ra; IL 13RA1; IL13 receptor alpha 1 chain; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; Interleukin 13 receptor alpha 1; Interleukin 13 receptor alpha 1 chain; interleukin 13 receptor subunit alpha 1; Interleukin-13 receptor subunit alpha-1; NR 4; NR4

UniProt

P78552

Accession Number

NP_001551.1

Expression System

HEK293 Cells

Tag

C-His-Fc

Sequence

Met 1-Thr 343

Applications

ELISA

Field of Research

Signal Transduction; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 97 % as determined by reducing SDS-PAGE.

Bioactivity

Immobilized cynomolgus IL-13 at 4 μg/ml (100 μl/well) can bind human IL13RA1-Fc with a linear ranger of 0.156-2. 5 μg/ml.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

65.0 kDa

Observed Molecular Weight

85-95 kDa

Species

Human