Recombinant Human LAIR2/CD306 Protein, Low Endotoxin

Specifications

Catalog number

PKSH031381-01

Size / count

5 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2), also known as CD306, is a 131 amino acid protein containing one lg-like C2-type domain. It is expressed as a soluble receptor exhibiting high affinity for various collagen molecules to which it binds in a hydroxyproline-dependent manner. LAIR2 is a member of the immunoglobulin superfamily and was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. LAIR2 is thought to be secreted and may help modulate mucosal tolerance. As a natural competitor for LAIR1, soluble LAIR2 prevents binding of human LAIR1 to collagens and LAIR1 cross-linking, thereby regulating its inhibitory potential. Accordingly, LAIR2 is suggested to perform an immunoregulatory function.

Synonyms

CD306; LAIR2; MGC71634; XXbac-BCX535A19.6

UniProt

Q6ISS4

Accession Number

NP_002279.2

Expression System

HEK293 Cells

Tag

None

Sequence

Met 1-Pro 152

Field of Research

Immunology

Endotoxin

< 0.005 EU per μg of the protein as determined by the LAL method.

Purity

> 94 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

14.1 kDa

Observed Molecular Weight

20 kDa

Species

Human