Recombinant Human Defensin/Beta-defensin 3/DEFB103 Protein (His Tag)

Specifications

Catalog number

PKSH031389

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Beta-defensin 3 is a member of the defensin family. Defensin family is comprised by microbicidal and cytotoxic peptides made by neutrophils. Members of the beta-defensin 3 family are highly similar in protein sequence. Beta-defensin 3 shows antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Beta-defensin 3 is abundantly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. It is also expressed in salivary gland, bone marrow, colon, stomach, polyp and larynx. However, in small intestine, it cannot be detected. Defensin has broad spectrum antimicrobial activity and may play an important role in innate epithelial defense. Beta-defensin 3 kills multiresistant S.aureus and vancomycin-resistent E.faecium. It has no significant hemolytic activity.

Synonyms

BD-3; DEFB-3; DEFB103; DEFB3; HBD3; HBP-3; HBP3; hBD-3

UniProt

P81534

Accession Number

P81534

Expression System

E.coli

Tag

N-His

Sequence

Gly 23-Lys 67

Field of Research

Microbiology; immunology

Endotoxin

Please contact us for more information.

Purity

> 99 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

7.3 kDa

Observed Molecular Weight

12 kDa

Species

Human