Recombinant Human Uteroglobin/SCGB1A1 Protein (His Tag)

Specifications

Catalog number

PKSH031418

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Uteroglobin (UG) ; also known as Secretoglobin 1A member 1 (SCGB1A1) ; Blastokinin; Clara cell secretor protein (CCSP) or Clara cell-specific 10-kDa protein (CC10) ; is the founding member of the secretoglobin family of small; secreted; disulfide-bridged dimeric proteins found only in mammals. This protein is mainly expressed in lung; with anti-inflammatory/immunomodulatory properties. Previous in vitro studies demonstrated that CCAAT/enhancer-binding proteins (C/EBPs) are the major transcription factors for the regulation of SCGB1A1 gene expression; whereas FOXA1 had a minimum effect on the transcription. Uteroglobin is a multifunctional protein with antiinflammatory/immunomodulatory properties. Uteroglobin inhibits soluble phospholipase A (2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone; retinols; polychlorinated biphenyls; phospholipids; and prostaglandins. In addition to its antiinflammatory activities; Uteroglobin manifests antichemotactic; antiallergic; antitumorigenic; and embryonic growth-stimulatory activities. The tissue-specific expression of the Uteroglobin gene is regulated by several steroid hormones; although a nonsteroid hormone; prolactin; further augments its expression in the uterus. Based on its anti-inflammatory and antiallergic properties; Uteroglobin is a potential drug target. The mechanism of Uteroglobin action is likely to be even more complex as it also functions via a putative receptor-mediated pathway.

Synonyms

CC10; CCPBP; CCSP; Clara cell phospholipid-binding protein; Clara cells 10 kDa secretory protein; SCGB1A1; Secretoglobin family 1A member 1; UGB; UP-1; UP1; Urinary protein 1; Urine protein 1; Uteroglobin

UniProt

P11684

Accession Number

P11684

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Asn 91

Applications

Cell culture

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 97 % as determined by reducing SDS-PAGE.

Bioactivity

4

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

9.2 kDa

Observed Molecular Weight

9.2 kDa

Species

Human