Recombinant Human CXADR/CAR Protein (His & Fc Tag)

Specifications

Catalog number

PKSH031425

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a type I transmembrane glycoprotein belonging to the CTX family of the Ig superfamily, and is essential for normal cardiac development in the mouse. Proposed as a homophilic cell adhesion molecule, CXADR is a component of the epithelial apical junction complex that is essential for the tight junction integrity, and probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) . Mature mouse CXADR structrually comprises a 218 aa extracellular domain (ECD) with a V-type (D1) and a C2-type (D2) Ig-like domain, a 21 aa transmembrane segment and a 107 aa intracellular domain, among which, D1 is thought to be responsible for homodimer formation in trans within tight junctions. The ECD of mouse CXADR shares 97%, 90% sequence identity with the corresponding regions of rat, human CXADR.

Synonyms

CAR; CVB3-Binding Protein; CXADR; Coxsackievirus B-Adenovirus Receptor; Coxsackievirus and Adenovirus Receptor; HCVADR; hCAR

UniProt

P78310

Accession Number

NP_001329.1

Expression System

HEK293 Cells

Tag

C-His-Fc

Sequence

Met 1-Gly 237

Applications

Cell culture

Field of Research

Signal Transduction; Microbiology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 92 % as determined by reducing SDS-PAGE.

Bioactivity

4

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

52.0 kDa

Observed Molecular Weight

60-65 kDa

Species

Human