Recombinant Human CD80/B7-1 Protein

Specifications

Catalog number

PKSH031476

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The B-lymphocyte activation antigen B7-1 (referred to as B7) ; also known as CD80; is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells; macrophages and dendritic cells. As costimulatory ligands; B7-1 which exists predominantly as dimer and the related protein B7-2; interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells; and thus constitute one of the dominant pathways that regulate T cell activation and tolerance; cytokine production; and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

Synonyms

Activation B7-1 antigen; B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; CD28LGB7-1 antigen; CD80; LAB7; T-lymphocyte activation antigen CD80

UniProt

P33681

Accession Number

NP_005182.1

Expression System

HEK293 Cells

Tag

None

Sequence

Met 1-Asn 242

Field of Research

Immunology; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 85 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

25.5 kDa

Species

Human