Recombinant Human IL2RG/CD132 Protein (aa 1-254, Fc Tag)

Specifications

Catalog number

PKSH031531-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The common gamma chain (γ c) (or CD132) ; also known as interleukin-2 receptor subunit gamma or IL2RG; is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations; and its gene is found on the X-chromosome of mammals. The common gamma chain (γ c) (or IL2RG) ; is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2; IL-4; IL-7; IL-9; IL-15 and interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (XSCID) is a rare and potentially fatal disease caused by mutations of IL2RG; the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross-linking data; the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor; together with the finding that IL-2R gamma associates with the IL-7 receptor; begins to elucidate why deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development; as seen in X-linked severe combined immunodeficiency.

Abbreviation

IL2RG/CD132

Synonyms

IMD; IL2RG; CD132; CIDX; IL-2RG; IMD4; P64; SCIDX; SCIDX1; Cytokine receptor common subunit gamma; gammaC; Interleukin-2 receptor subunit gamma; common &gamma- chain-n; IL-2R&gamma

UniProt

P31785

Accession Number

P31785

Expression System

HEK293 Cells

Tag

C-hFc

Sequence

Met 1-Asn254

Field of Research

Cancer; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 99 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

54.4 kDa

Observed Molecular Weight

71 kDa

Species

Human