Recombinant Human RELT/TNFRSF19L Protein (His & Fc Tag)

Specifications

Catalog number

PKSH031544

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Receptor expressed in lymphoid tissues (RELT) ; also known as tumor necrosis factor receptor superfamily; member 19-like (TNFRSF19L) ; is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1. RELT/TNFRSF19L is capable of stimulating T-cell proliferation in the presence of CD3 signaling; which suggests its regulatory role in immune response. RELT/TNFRSF19L is a type I transmembrane glycoprotein with a cysteine-rich extracellular domain; possessing significant homology to other members of the TNFR superfamily; especially TNFRSF19; DR3; OX40; and LTbeta receptor. RELT/TNFRSF19L is able to activate the NF-kappaB pathway and selectively binds tumor necrosis factor receptor-associated factor 1. RELT/TNFRSF19L is able to activate the NF-κ B pathway and selectively binds tumor necrosis factor receptor-associated factor 1. Although the soluble form of RELT fusion protein does not inhibit the one-way mixed lymphocyte reaction; immobilized RELT/TNFRSF19L is capable of costimulating T-cell proliferation in the presence of CD3 signaling.

Synonyms

RELT; Receptor expressed in lymphoid tissues; TNFRSF19L; Tumor necrosis factor receptor superfamily member 19L

UniProt

Q969Z4

Accession Number

NP_116260.2

Expression System

HEK293 Cells

Tag

C-His-Fc

Sequence

Met 1-Ala 160

Field of Research

Signal Transduction

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

42 kDa

Observed Molecular Weight

55-60 kDa

Species

Human