Recombinant Human CD208/LAMP3/DC-LAMP Protein (His Tag)

Specifications

Catalog number

PKSH031547

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Dendritic cell-lysosomal associated membrane protein (DC-LAMP) /CD208, also known as LAMP3, is a member of the lysosomal associated membrane protein (LAMP) family, which is specifically expressed by human dendritic cells (DCs) upon activation and therefore serves as marker of human DC maturation. Confocal and immunoelectron microscopy showed that mouse DC-LAMP protein co-localizes with lbm180, a specific marker for the limiting membrane of lamellar bodies that contain surfactant protein B. The present study demonstrates that DC-LAMP is constitutively expressed by mouse, sheep, and human type II pneumocytes. DC-LAMP is constitutively expressed in normal type II pneumocytes. DC-LAMP is detected first in activated human DC within MHC class II molecules-containing compartments just before the translocation of MHC class II-peptide complexes to the cell surface, suggesting a possible involvement in this process. Furthermore, overexpression of LAMP3 is actively involved in tumor invasion through increased migration into lymph-vascular spaces.

Synonyms

CD208; DC LAMP; DC-LAMP; DCLAMP; LAMP; LAMP-3; TSC403

UniProt

Q9UQV4

Accession Number

NP_055213.2

Expression System

HEK293 Cells

Tag

C-His

Sequence

Lys 28-Thr 381

Field of Research

Tags & Cell Markers; Cancer; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

39.0 kDa

Observed Molecular Weight

70-90 kDa

Species

Human