Recombinant Human IL-20RA/IL-20R1 Protein (His Tag)

Specifications

Catalog number

PKSH031633

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin 20 receptor, alpha subunit (IL20RA/IL-20RA) also known as IL-20 receptor subunit alpha, Cytokine receptor class-II member 8, interleukin-20 receptor I, and interleukin-20 receptor subunit alpha, is a subunit for the interleukin-20 receptor. IL20RA/IL-20RA belongs to the type II cytokine receptor family. This cytokine is a receptor for interleukin 20 (IL20), a cytokine that may be involved in epidermal function. The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B) . IL20RA forms heterodimer with IL20RB, and the complex serves as a receptor for IL19, IL20 and IL24. All three are capable of signaling through IL-20RA/IL-20RB complex. The ligand binding to receptor B creating a high-affinity binding site for the receptor A which is recruited to complete the complex. In addition, IL20RA also forms a heterodimer with the unique and specific receptor IL10RB and functions as the receptor for IL26. IL20RA is widely expressed with highest levels in skin, testis and brain. The expression of both IL20RA and IL20RB is found to be upregulated in psoriatic skin lesions on keratinocytes.

Abbreviation

IL-20RA/IL-20R1

Synonyms

UNQ; PRO; Cytokine Receptor Class-II Member; Cytokine Receptor Family 2 Member; CRF2; IL-20R; ZcytoR; CRF2-8; Cytokine Receptor Class-II Member 8; Cytokine Receptor Family 2 Member 8; IL-20 Receptor Subunit Alpha; IL-20R1; IL-20RA; IL-20R-Alpha; Interleukin-20 Receptor Subunit Alpha; ZcytoR7; IL20RA; UNQ681; PRO1315; alpha; class II cytokine receptor ZCYTOR7; CRF2 8; Cytokine receptor class II member 8; I20RA; IL 20R alpha; IL 20R1; Interleukin 20 receptor; Interleukin 20 receptor alpha chain; interleukin-20 receptor I

Accession Number

NP_055247.21

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Lys 250

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

26.8 kDa

Observed Molecular Weight

40-45 kDa

Species

Human