Recombinant Human SLITRK1 Protein (His & Fc Tag)

Specifications

Catalog number

PKSH031668

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

SLITRK1 (Slit and Trk-like family member 1) is a integral membrane protein belonging to the SLITRK family consists of at least 6 members (SLITRK1-6) . They are named and characterized by the presence of two leucine-rich repeats (LRRs) in the extracellular domain similar to those found in a secreted axonal growth-controlling protein; Slit; as well as a C-terminal domain with homology to Trk neurotrophin tyrosine kinase receptors. Expression of SLITRKs are highly restricted to neural tissues; and are identified as the neuronal components modulating the neurite outgrowth. More specifically; SLITRK1 expression is found in the mature neurons of the cerebrum; thalamus and hippocampus; and induces unipolar neurites in cultured neuronal cells. Human SLITRK1 is a 696 amino acid precursor protein; and one truncating frameshift mutation (448 aa) has been linked to Tourette's syndrome; a genetically influenced developmental neuropsychiatric disorder characterized by chronic vocal and motor tics. In addition; all SLITRK genes are differentially expressed in brain tumors; such as astrocytoma; oligodendroglioma; glioblastoma; and are suggested to be useful molecular indicators of brain tumor properties.

Synonyms

FLJ54428; KIAA0918; KIAA1910; LRRC12; RP11-395N17.1; SLITRK1; TTM

UniProt

Q96PX8

Accession Number

NP_443142.1

Expression System

HEK293 Cells

Tag

C-His-Fc

Sequence

Met 1-Ser 616

Field of Research

Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

95.0 kDa

Observed Molecular Weight

130-150 kDa

Species

Human