Recombinant Human JAM-A/F11R Protein (Fc Tag)

Specifications

Catalog number

PKSH031772

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Junctional adhesion molecule-A (JAM-A) ; also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321) ; is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells; as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses) . It is also a ligand for the integrin LFA1; involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily; JAM-A protein involves in platelet adhesion; secretion and aggregation; and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition; it may be a potential therapeutic target for breast cancer.

Synonyms

CD321; F11R; JAM-1; JAM-A; JAM1; JAMA; JCAM; Junctional Adhesion Molecule 1; Junctional Adhesion Molecule A; KAT; PAM-1; Platelet Adhesion Molecule 1; Platelet F11 Receptor

UniProt

Q6FIB4

Accession Number

NP_058642.1

Expression System

HEK293 Cells

Tag

C-hFc

Sequence

Met 1-Ala 242

Applications

Cell culture

Field of Research

Signal Transduction; Cardiovascular

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

4

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

50.0 kDa

Observed Molecular Weight

61 kDa

Species

Human