Recombinant Human IL-1R8/IL1RAPL1 Protein (aa 1-354, His Tag)

Specifications

Catalog number

PKSH031795-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) is a member of interleukin-1 receptor family. The protein structurally comprises three extracellular immunoglobulin domains; which presumably mediate binding of an as yet unidentified ligand; a transmembrane region; and an intracellular domain; which is likely to enable signalling via the NFkB pathway. The means of signalling is almost certain to be identical to that used by the IL1R family and the more distally related Toll protein. L1RAPL1 protein physically interacts via its 150 aa C-terminal domain with neuronal calcium sensor-1 (NCS-1) ; a protein widely expressed in neurons and the related chromaffin and PC12 cells. IL1RAPL1 is an integral membrane protein responsible for a nonsyndromic form of mental retardation (MR) . It is suggested to affect human cognitive ability to some extent; especially the memory and concentration capability.

Abbreviation

IL-1R8/IL1RAPL1

Synonyms

IL1R; OPHN; TIGIRR; MRX; IL1RAPL1; IL1R8; IL1RAPL; MRX10; MRX21; MRX34; OPHN4; TIGIRR-2; IL1RAPL-1; IL-1RAPL-1; IL-1-RAPL-1; Interleukin-1 Receptor Accessory Protein-Like 1; Oligophrenin-4; Three Immunoglobulin Domain-Containing IL-1 Receptor-Related 2; X-Linked Interleukin-1 Receptor Accessory Protein-Like 1

UniProt

Q9NZN1

Accession Number

NP_055086.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Leu 354

Field of Research

Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

40 kDa

Observed Molecular Weight

50-55 kDa

Species

Human