Recombinant Human IL36G/IL1F9 Protein (aa 18-169)

Specifications

Catalog number

PKSH031851

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Junctional adhesion molecules (JAMs) are endothelial and epithelial adhesion molecules involved in the recruitment of circulating leukocytes to inflammatory sites. JAML (Junctional adhesion molecule-like) ; also known as AMICA1 (Adhesion molecule interacting with CXADR antigen 1) ; a protein related to the JAM family; is restricted to leukocytes and promotes their adhesion to endothelial cells. It contains 2 extracellular immunoglobulin-like domains; a transmembrane segment; and a cytoplasmic tail involved in activation signaling. Monocytic JAML/AMICA1 plays a critical role in regulating monocyte transendothelial migration (TEM) probably via binding to the endothelial coxsackie and adenovirus receptor (CAR) and other tight junction-associated adhesive molecules. The Expression of JAML/AMICA1 is restricted to the hematopoietic tissues with the exception of liver. JAML may function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes; JAML/AMICA1 also enhances myeloid leukemia cell adhesion to endothelial cells.

Abbreviation

IL36G/IL1F9

Synonyms

UNQ; PRO; IL1F; IL1H; IL-1-related protein; Interleukin-1 homolog; IL-1F; IL-1H; IL1RP; IL-1RP; IL36G; IL-1F9; IL-1H1; IL-1RP2; IL1E; IL1F9; IL1H1; IL1RP2; IL-1 epsilon; IL-1-related protein 2; Interleukin-1 homolog 1; Interleukin-36 gamma; UNQ2456; PRO5737

UniProt

Q9NZH8

Accession Number

NP_062564

Expression System

E.coli

Tag

None

Sequence

Ser18-Asp169

Field of Research

Immunology

Endotoxin

Please contact us for more information.

Purity

> 96 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

17 kDa

Observed Molecular Weight

16 kDa

Species

Human