Recombinant Human IL36G/IL1F9 Protein

Specifications

Catalog number

PKSH031852

Size / count

50 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body, and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumours, and thus has been suggested to play an important role in tumour progression and the development of metastasis in certain human carcinomas.

Abbreviation

IL36G/IL1F9

Synonyms

UNQ; PRO; IL1F; IL1H; IL-1-related protein; Interleukin-1 homolog; IL-1F; IL-1H; IL1RP; IL-1RP; IL36G; IL-1F9; IL-1H1; IL-1RP2; IL1E; IL1F9; IL1H1; IL1RP2; IL-1 epsilon; IL-1-related protein 2; Interleukin-1 homolog 1; Interleukin-36 gamma; UNQ2456; PRO5737

UniProt

Q9NZH8

Accession Number

Q9NZH8-1

Expression System

E.coli

Tag

None

Sequence

Met 1-Asp 169

Field of Research

Immunology

Endotoxin

Please contact us for more information.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

18.9 kDa

Observed Molecular Weight

18 kDa

Species

Human