Recombinant Human IL36G/IL1F9 Protein (aa 18-169, His Tag)

Specifications

Catalog number

PKSH031853

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Vaccinia H1-related phosphatase (VHR) is classified as a dual-specificity phosphatase (DUSP) ; and the other name is dual-specificity phosphatase 3 (DUSP3) . DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. Unlike typical DUSPs; VHR lacks mitogen-activated protein kinase (MAPK) -binding domain; and shows poor activity against MAPKs. VHR often act on bisphosphorylated protein substrates; it displays a strong preference for dephosphorylating phosphotyrosine residues over phosphothreonine residues. VHR has been identified as a novel regulator of extracellular regulated kinases (ERKs) . VHR is responsible for the rapid inactivation of ERK following stimulation and for its repression in quiescent cells. VHR is a negative regulator of the Erk and Jnk pathways in T cells and; therefore; may play a role in aspects of T lymphocyte physiology that depend on these kinases.

Abbreviation

IL36G/IL1F9

Synonyms

UNQ; PRO; IL1F; IL1H; IL-1-related protein; Interleukin-1 homolog; IL-1F; IL-1H; IL1RP; IL-1RP; IL36G; IL-1F9; IL-1H1; IL-1RP2; IL1E; IL1F9; IL1H1; IL1RP2; IL-1 epsilon; IL-1-related protein 2; Interleukin-1 homolog 1; Interleukin-36 gamma; UNQ2456; PRO5737

UniProt

Q9NZH8

Accession Number

NP_062564

Expression System

E.coli

Tag

N-His

Sequence

Ser18-Asp169

Field of Research

Immunology

Endotoxin

Please contact us for more information.

Purity

> 98 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

19.1 kDa

Observed Molecular Weight

19 kDa

Species

Human