Recombinant Human GAPDH Protein (His Tag)

Specifications

Catalog number

PKSH031882

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Glyceraldehyde 3-phosphate dehydrogenase (GAPDH or G3PDH) is an enzyme of about 37kDa that is consisdered as a cellular enzyme involved in glycolysis. It catelyzes the sixth step of glycolysis. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. Its role as a mediator for cell death has also been highlighted. A recent report suggests that GAPDH may be genetically associated with late-onset of Alzheimer's disease. Besides, deprenyl, which has originally been used as a monoamine oxidase inhibitor for Parkinson's disease, binds to GAPDH and displays neuroprotective actions.

Synonyms

G3PD; GAPD; HEL-S-162eP

UniProt

P04406

Accession Number

P04406

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Glu 335

Field of Research

Signal Transduction; Cancer; Isotypeloading control; metabolism

Endotoxin

Please contact us for more information.

Purity

> 93 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

38 kDa

Observed Molecular Weight

38 kDa

Species

Human