Recombinant Human/Mouse/Rat/Rhesus/Canine BMP-2 Protein

Specifications

Catalog number

PKSH031986-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 protein may play an important role in the progression of glioma.

Synonyms

BDA2; BDA2A; BMP-2; BMP2; BMP2A

UniProt

P12643

Accession Number

NP_001191.1

Expression System

E.coli

Tag

None

Sequence

Gln283-Arg396

Applications

Cell culture

Field of Research

Signal Transduction; Cardiovascular; Cancer; Stem cells

Endotoxin

Please contact us for more information.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse osteoblastic cells. The ED50 for this effect is typically 0.5-2 μg/ml.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

13 kDa

Species

Human