Recombinant Human PGD2 Synthase/PTGDS Protein (His Tag)

Specifications

Catalog number

PKSH032006

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

PTGDS; also known as L-PGDS; belongs to the calycin superfamily; lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic molecules such as steroids; bilins; retinoids; and lipids. PTGDS is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of PGH2 to PGD2. It is involved in smooth muscle contraction/relaxation and a variety of central nervous system functions. PTGDS may have an anti-apoptotic role in oligodendrocytes. It binds small non-substrate lipophilic molecules; including biliverdin; bilirubin; retinal; retinoic acid and thyroid hormone; and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.

Synonyms

Beta-Trace Protein; Cerebrin-28; Glutathione-Independent PGD Synthase; Lipocalin-Type Prostaglandin-D Synthase; PDS; PGD2 Synthase; PGDS; PGDS2; PTGDS; Prostaglandin D Synthase; Prostaglandin-D2 Synthase; Prostaglandin-H2 D-Isomerase

UniProt

P41222

Accession Number

P41222

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Gln190

Field of Research

Signal Transduction

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 80 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

20.1 kDa

Observed Molecular Weight

28 kDa

Species

Human