Recombinant Human EphB2 Protein (Fc Tag)

Specifications

Catalog number

PKSH032012-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Ephrin type-B receptor 2 (EPHB2) belongs to the protein kinase superfamily and Ephrin receptor subfamily. EPHB2 contains 1 Eph LBD domain; 2 fibronectin type-III domains; 1 protein kinase domain and 1 SAM domain. Ephrin receptors and their ligands; the ephrins; mediate numerous developmental processes; particularly in the nervous system. Based on their structures and sequence relationships; ephrins are divided into the ephrin-A (EFNA) class; which are anchored to the membrane by a glycosylphosphatidylinositol linkage; and the ephrin-B (EFNB) class; which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family.

Abbreviation

EphB2

Synonyms

CAPB; DRT; EK5; EPHB2; EPHT3; ERK; Ephrin type-B receptor 2; Hek5; PCBC; Tyro5

UniProt

P29323

Accession Number

Q6NVW1

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Val19-Ser482

Field of Research

Cardiovascular, Neuroscience, Signal Transduction, Stem Cells, Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

78.5 kDa

Observed Molecular Weight

95-120 kDa

Species

Human