Recombinant Human CSF1R/CD115 Protein (aa 20-517, His Tag)

Specifications

Catalog number

PKSH032013-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region. CSF1R is expressed primarily on cells of the monocyte/macrophage lineage; dendritic cells; stem cells and in the developing placenta. CSF1 and its receptor (CSF1R; product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. It plays an important role in the regulation of osteoclast proliferation and differentiation; the regulation of bone resorption; and is required for normal bone and tooth development. It is required for normal male and female fertility; and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases; such as rheumatoid arthritis; glomerulonephritis; atherosclerosis; and allograft rejection.

Abbreviation

CSF1R; CD115

Synonyms

C-FMS; CD115; CSF-1 receptor; CSF-1-R; CSF-1R; CSF1R; FIM2; FMS; HDLS; M-CSF-R; MCSF Receptor ; Macrophage colony-stimulating factor 1 receptor; Proto-oncogene c-Fms

Accession Number

P07333

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ile20-Pro517

Field of Research

Signal Transduction; Cardiovascular; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

55.9 kDa

Observed Molecular Weight

80-110 kDa

Species

Human