Recombinant Human 4-1BBL/TNFSF9 Protein (His Tag)

Specifications

Catalog number

PKSH032023-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1BBL is a 254 amino acids cytokine that is expressed in brain; placenta; lung; skeletal muscle and kidney. TNFSF9 has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine may have a role in activation-induced cell death (AICD) and cognate interactions between T-cells and B-cells/macrophages. It has also been shown to be required for the optimal CD8 responses in CD8 T cells; and is thought to be involved in T cell-tumor cell interaction.

Abbreviation

4-1BBL; TNFSF9

Synonyms

4-1BB ligand;4-1BBL; TNFSF9; Tumor necrosis factor ligand superfamily member 9

UniProt

P41273

Accession Number

P41273

Expression System

E.coli

Tag

C-His

Sequence

Arg71-Asp 140

Applications

Cell culture

Field of Research

Cancer; immunology

Endotoxin

< 0.1 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

20.4 kDa

Observed Molecular Weight

20 kDa

Species

Human