Recombinant Human ALK-2/ACVR1 Protein (Human Cells, His Tag)

Specifications

Catalog number

PKSH032036-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Activin receptor type-1; also known as Activin receptor type I; Activin receptor-like kinase 2; Serine/threonine-protein kinase receptor R1; TGF-B superfamily receptor type I; ACVRLK2 and ACVR1; is a single-pass type I membrane protein. ACVR1 is expressed in normal parenchymal cells; endothelial cells; fibroblasts and tumor-derived epithelial cells. ACVR1 belongs to the protein kinase superfamily. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins; composed of a ligand-binding extracellular domain with cysteine-rich region; a transmembrane domain; and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding; resulting in phosphorylation of type I receptors by type II receptors. ACVR1 signals a particular transcriptional response in concert with activin type II receptors.

Abbreviation

ALK-2; ACVR1

Synonyms

ACTR-I; ACVR1; ACVR1A; ACVRLK2; ALK-2; ALK2; Activin Receptor Type I; Activin Receptor Type-1; Activin Receptor-Like Kinase 2; FOP; SKR1; Serine/Threonine-Protein Kinase Receptor R1; TGF-B Superfamily Receptor Type I; TSR-I

UniProt

Q04771

Accession Number

Q04771

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met21-Val124

Field of Research

Signal Transduction; epigenetics and nuclear signal; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

12.6 kDa

Observed Molecular Weight

17 kDa

Species

Human